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April 22, 2020
Auranofin, a gold-infused drug originally developed in 1985 and approved by the FDA to treat rheumatoid arthritis, is effective at inhibiting the spread of the novel coronavirus, according to researchers at Georgia State University.
In the preliminary study, human cells infected with the virus were treated with Auranofin, and within 48 hours of treatment, the amount of virus within the cells dropped by 95 percent. Treatment also resulted in significant reduction of coronavirus-induced inflammation.
Like all viruses, SARS-CoV-2 (the virus that causes the disease COVID-19) cannot reproduce on its own. Instead it uses host cell proteins to manufacture copies of itself.
“Effective drugs need to interfere with this replication process, shutting down the virus’s ability to proliferate inside the host,” said Hussin Rothan, a post-doctoral researcher at Georgia State and co-author of the study.
Because the drug has already been approved by the U.S. Food & Drug Administration, it could potentially be fast-tracked to patients in need.
“Drug repurposing is the fastest way to get a treatment for SARS-CoV-2 because it’s already been established that these medicines are safe to use in humans,” said Mukesh Kumar, lead author of the study and assistant professor of biology.
Auranofin is a chemical compound containing particles of gold, an element known to have anti-inflammatory properties for nearly a century.
The Georgia State University researchers explained that Auranofin also dramatically reduced the expression of cytokines — signaling proteins that draw immune cells to the site of infection— caused by SARS-CoV-2. Normally, the immune system works by fighting off invading pathogens and repairing damage to the body’s tissues.
But many coronavirus-infected patients who die do so because of something called a “cytokine storm,” in which the body’s immune response spirals out of control, killing healthy tissue and leading to organ failure.
According to Kumar, the research seems to indicate that the drug not only could inhibit the replication of SARS-CoV-2, mitigating the infection, but also reduce the associated lung damage that often leads to severe respiratory distress and even death.
Precious metal has been used in medicine since ancient times, and more recently, scientists have explored gold compounds as effective treatments for HIV, cancer, neurodegenerative disorders and parasitic and bacterial infections.
Kumar and his team plan to test the drug in animal models to learn more about how it affects infection and illness, and whether it is effective in treating the disease.
The researchers at Georgia State University have made their paper publicly available for the global research and healthcare community on the preprint website bioRxiv.
Credits: Hussin Rothan image courtesy of Georgia State University. Graphic by https://www.scientificanimations.com / CC BY-SA.